A ground-breaking, year-long investigation by Youth Today has uncovered ample evidence that many youths incarcerated in American juvenile facilities are getting potent anti-psychotic drugs intended for bipolar or schizophrenic patients, even when they have not been diagnosed with either disorder.
The findings are derived from records of state juvenile systems that provided sufficiently detailed information on their use of these anti-psychotics – called “atypicals.” Only 16 states responded to a nationwide survey by Youth Today, meaning that a majority of states either would not or could not demonstrate that they were even monitoring the use of these medications on incarcerated juveniles.
The atypical anti-psychotics were being used to treat a wide variety of diagnoses, including intermittent explosive disorder, oppositional defiant disorder and even the more common attention deficit and hyperactivity disorder.
Critics believe most of these diagnoses are simply a cover for the fact that prisons now use drugs as a substitute for banned physical restraints that once were used on juveniles who aggressively acted out.
“Fifty years ago, we were tying kids up with leather straps, but now that offends people, so instead we drug them,” says Robert Jacobs, a former Florida psychologist and lawyer who now practices psychology in Australia. “We cover it up with some justification that there is some medical reason, which there is not.”
Supporters of prescribing the atypicals believe using the drugs as sedation isn’t necessarily bad.
“It prepares youth so they can respond to treatment,” says LeAdelle Phelps, a former juvenile facility director and adolescent psychologist. “By reducing aggression and by having calming, soothing effects,” the anti-psychotic makes residents “more malleable.”
Others disagree, arguing that the drugs may interfere with attempts at meaningful therapy.
But there have been no studies on widespread use of the atypicals on juvenile offenders. The Government Accountability Office is investigating various state policies for placing foster children on atypicals, which in those cases are paid for by federally matched Medicaid.
But federal Medicaid money, by statute, cannot fund care for anyone incarcerated for a crime – adult or juvenile. That means funds for medications issued to juvenile inmates come from state sources.
For more than a year, Youth Today has been working to find out how much states have been spending on anti-psychotic drugs for incarcerated juveniles, and why.
Atypicals and youth: a primer
Nobody fully knows how anti-psychotic medications do their job, but the consensus is that the drugs can quell psychotic episodes by interacting with neurotransmitters in the brain called Dopamine receptors.
The drug binds with the receptors, which limits the amoung of dopamine that is transmitted. That can quell the hallucinations and voices heard by people suffering from schizophrenia or who have psychotic episodes brought on by bipolar disorder.
But because many of the drugs may also bind with and limit other receptors – such as serotonin and oxytocin – they can numb the overall impulses and actions of most people who take them, whether they have a psychotic disorder or not.
Anti-psychotic drugs have been a part of the psychiatric medical arsenal since the 1950s. The first iteration, haloperidol, often prescribed under the brand name Haldol, has long been used in this country either to treat or sedate institutionalized people. It poses serious downsides pertaining to motor control; Haldol has been known to cause tremors, muscle stiffness and twitching in patients.
The second generation of anti-psychotic drugs – the atypicals – emerged in the late 1990s and early 2000s. The five most frequently used are Abilify (aripiprazole), Geodon (ziprasidone), Seroquel (quetiapine), Risperdal (risperidone) and Zyprexa (olanzapine).
The drugs show significantly lower rates of haloperidol’s motor control side effects. But they have their own set of potential side effects in addition to sedation, including significant weight gain and early onset of diabetes.
Those side effects are magnified for adolescents, says Mark Olfson, professor of clinical psychiatry at Columbia University.
“There is a reasonable body of evidence that adolescents are more sensitive to the metabolic side effects,” Olfson says.
Those risks are augmented further in some juvenile facilities by a lack of time devoted to physical activity.
The Food and Drug Administration approved Abilify for use in adolescent patients with schizophrenia or bipolar mania in 2007. Since then, similar approval has been given for Seroquel, Risperdal and Zyprexa. Geodon has not been approved for treatment of youth.
But doctors need not wait for FDA approval to prescribe a drug off-label, and when it came to poor children, they certainly did not wait for the FDA to approve atypical anti-psychotics. Ken Kramer, a researcher with the Citizens Commission on Human Rights of Florida, obtained detailed annual Medicaid expenditures for the five most prescribed atypicals in 30 states.